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They mainly trigger apoptosis of CD4 + T cells in vivo ( 86) by fostering and maintaining an anti-inflammatory IL-10 + phenotype, while also slowing down the activation, maturation, and proliferation of CD4 + T cells (87, 88)

Comparison of endothelin-1-mediated tissue tension and calcium mobilization effects in isolated rabbit corpus cavernosum

Lavigne EG, Buttigieg D, Steinschneider R, Burstein ES (2021) Pimavanserin promotes trophic factor release and protects cultured primary dopaminergic neurons exposed to MPP+ in a GDNF-dependent manner